In advanced age, the stem cells responsible for muscle regeneration switch from reversible quiescence to irreversible senescence. Targeting a driver of senescence revives muscle stem cells and restores regeneration. See Article p.316
References
Ruiz, J. R. et al. Br. Med. J. 337, a439 (2008).
de Brito, L. B. B. et al. Eur. J. Prev. Cardiol. http://dx.doi.org/10.1177/2047487312471759 (2012).
Sousa-Victor, P. et al. Nature 506, 316–321 (2014).
Cheung, T. H. & Rando, T. A. Nature Rev. Mol. Cell Biol. 14, 329–340 (2013).
Liu, L. et al. Cell Rep. 4, 189–204 (2013).
Orford, K. W. & Scaden, D. T. Nature Rev. Genet. 9, 115–128 (2008).
Jang, Y. C., Sinha, M., Cerletti, M., Dall'Osso, C. & Wagers, A. J. Cold Spring Harb. Symp. Quant. Biol. 76, 101–111 (2011).
Chakkalakal, J. V., Jones, K. M., Basson, M. A. & Brack, A. S. Nature 490, 355–360 (2012).
Cousin, W. et al. PLoS ONE 8, e63528 (2013).
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).
Baker, D. J. et al. Nature 479, 232–236 (2011).
Li, H. et al. Nature 460, 1136–1139 (2009).
Menendez, S. et al. Aging Cell 11, 41–50 (2012).
Pajcini, K. V., Corbel, S. Y., Sage, J., Pomerantz, J. H. & Blau, H. M. Cell Stem Cell 7, 198–213 (2010).
Shyh-Chang, N. et al. Cell 155, 778–792 (2013).
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Li, M., Belmonte, J. Genetic rejuvenation of old muscle. Nature 506, 304–305 (2014). https://doi.org/10.1038/nature13058
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DOI: https://doi.org/10.1038/nature13058
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