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Cancer therapy

Tumours switch to resist

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Tumour cells can respond to targeted immune-cell therapies by losing proteins that mark them as being cancerous. Subverting this resistance mechanism may lead to more durable cancer-treatment strategies. See Letter p.412

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Figure 1: Escape by dedifferentiation.

Notes

  1. *This article and the paper under discussion1 were published online on 10 October 2012.

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Authors and Affiliations

  1. Antoni Ribas and Paul C. Tumeh are in the Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California 90095-1782, USA.,

    Antoni Ribas & Paul C. Tumeh

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  1. Antoni Ribas
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  2. Paul C. Tumeh
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Correspondence to Antoni Ribas.

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Ribas, A., Tumeh, P. Tumours switch to resist. Nature 490, 347–348 (2012). https://doi.org/10.1038/nature11489

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