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MicroRNA-10b and breast cancer metastasis

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Abstract

Arising from: L. Ma, J. Teruya-Feldstein & R. A. Weinberg Nature 449, 682–688 (2007)10.1038/nature06174; Ma et al. reply

MicroRNAs regulate messenger RNA expression but are frequently dysregulated in tumours. Ma et al.1 report that overexpression of microRNA-10b (miR-10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas correlates with clinical progression. We tested this in patients with primary breast cancer, of whom 92 had nodal metastases at diagnosis and 127 were node-negative. We found no significant association between miR-10b levels and metastasis or prognosis. Although we concede that miR-10b may have a biological effect in a few cells at the growing edge of a tumour, we believe that it is unlikely to correlate in whole tumour samples with clinical progression.

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Figure 1: miR-10b is not significantly associated with metastasis.

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Authors and Affiliations

  1. Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK

    Harriet E. Gee, Francesca M. Buffa, Helen Sheldon & Adrian L. Harris

  2. Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford OX3 7BN, UK

    Carme Camps, Stefano Colella & Jiannis Ragoussis

  3. ‡ Department of Medicine and Flinders University, Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia,

    Jonathan M. Gleadle

Authors
  1. Harriet E. Gee
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  2. Carme Camps
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  3. Francesca M. Buffa
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  4. Stefano Colella
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  5. Helen Sheldon
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  6. Jonathan M. Gleadle
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  7. Jiannis Ragoussis
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  8. Adrian L. Harris
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Gee, H., Camps, C., Buffa, F. et al. MicroRNA-10b and breast cancer metastasis. Nature 455, E8–E9 (2008). https://doi.org/10.1038/nature07362

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  • DOI: https://doi.org/10.1038/nature07362

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