T cells of the immune system recognize lipids, as well as peptides, extending our ideas about such target antigens. A crystal structure of a T-cell receptor docked to antigen shows how a sugar controls lipid recognition.
Notes
This article and the paper concerned4 were published online on 20 June 2007.
References
Calabi, F. & Milstein, C. Nature 323, 540–543 (1986).
Porcelli, S., Morita, C. T. & Brenner, M. B. Nature 360, 593–597 (1992).
Beckman, E. M. et al. Nature 372, 691–694 (1994).
Borg, N. A. et al. Nature 448, 44–49 (2007).
Grant, E. P. et al. J. Exp. Med. 189, 195–205 (1999).
Cui, J. et al. Science 278, 1623–1626 (1997).
Moody, D. B., Zajonc, D. M. & Wilson, I. A. Nature Rev. Immunol. 5, 387–399 (2005).
Kawano, T. et al. Science 278, 1626–1629 (1997).
Mattner, J. et al. Nature 434, 525–529 (2005).
Kinjo, Y. et al. Nature Immunol. 7, 978–986 (2006).
Gadola, S. D. et al. J. Exp. Med. 203, 699–710 (2006).
Kjer-Nielsen, L. et al. J. Exp. Med. 203, 661–673 (2006).
Hahn, M., Nicholson, M. J., Pyrdol, J. & Wucherpfennig, K. W. Nature Immunol. 6, 490–496 (2005).
Rudolph, M. G., Stanfield, R. L. & Wilson, I. A. Annu. Rev. Immunol. 24, 419–466 (2006).
Adams, E. J., Chien, Y. H. & Garcia, K. C. Science 308, 227–231 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moody, D. How a T cell sees sugar. Nature 448, 36–37 (2007). https://doi.org/10.1038/nature05890
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature05890
- Springer Nature Limited