Intramembrane proteases have attracted much attention because of their biological and medical value. The first crystal structure of one of these enzymes begins to solve the mystery of how they work.
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This article and the paper concerned3 were published online on 11 October 2006.
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Freeman, M. Enzyme theory holds water. Nature 444, 153–155 (2006). https://doi.org/10.1038/nature05305
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DOI: https://doi.org/10.1038/nature05305
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