Skip to main content
SpringerLink
Log in

Organizational challenges in clinical genomic research

  • Commentary
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Genome sequence data are enabling clinical genomic investigation, in which the characteristics of human patients are explored using comprehensive inventories of biomolecules. Successful investigators must navigate rapid technological change, collect and analyse large volumes of data, and engage systems of clinical care. Such projects will increasingly rely on fully integrated multidisciplinary teams, demanding new organizational models in academic biomedical research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Goldstein, J. L. & Brown, M. S. The clinical investigator: bewitched, bothered, and bewildered — but still beloved. J. Clin. Invest. 99, 2803–2812 (1997).

    Article  CAS  Google Scholar 

  2. Galambos, L. & Sewell, J. E. Confronting AIDS: Science and Business Cross a Unique Frontier (Merck, Whitehouse Station, New Jersey, 1998).

  3. Kennedy, D. Multiple authors, multiple problems. Science 301, 733 (2003).

    Article  CAS  Google Scholar 

  4. Editorial. Who'd want to work in a team? Nature 424, 1 (2003).

  5. Gray, M. L. & Bonventre, J. V. Training PhD researchers to translate science to clinical medicine: closing the gap from the other side. Nature Med. 8, 433–436 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. AltshulerGray LLC, 61 Dean Road, Brookline, 02445, Massachusetts, USA

    Jill S. Altshuler

  2. Departments of Genetics and Medicine, Harvard Medical School and Masschusetts General Hospital, and Broad Institute, 55 Fruit Street, Wellman 8, Boston, 02114, Massachusetts, USA

    David Altshuler

Authors
  1. Jill S. Altshuler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Altshuler
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

J.S.A. is a principal of AltshulerGray, a for-profit consultancy that gives advice on the organization and management of biomedical research enterprises.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Altshuler, J., Altshuler, D. Organizational challenges in clinical genomic research. Nature 429, 478–481 (2004). https://doi.org/10.1038/nature02629

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature02629

  • Springer Nature Limited

This article is cited by

Search

Navigation