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Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

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Acknowledgements

We thank Ms Yumiko Oguchi, Department of Pediatrics, Shinshu University School of Medicine, for her technical support.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan

    K Matsuda, C Iwashita & T Honda

  2. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan

    Y Nakazawa, T Kurata, K Hirabayashi, S Saito, M Tanaka, K Yoshikawa, R Yanagisawa, K Sakashita & K Koike

  3. Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan

    S Sasaki

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  1. K Matsuda
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  2. Y Nakazawa
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  3. C Iwashita
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  4. T Kurata
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  5. K Hirabayashi
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  6. S Saito
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  7. M Tanaka
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  8. K Yoshikawa
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  9. R Yanagisawa
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  10. K Sakashita
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  11. S Sasaki
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  12. T Honda
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  13. K Koike
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Corresponding author

Correspondence to K Koike.

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The authors declare no conflict of interest.

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Author Contributions

KK and KM designed and performed the research, collected the samples, analyzed the data and wrote the paper. YN designed the research. CI performed the research. TK, KH, SS, MT, KY, RY, KS and SS collected the samples and analyzed the data. All the authors read and approved the manuscript.

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Matsuda, K., Nakazawa, Y., Iwashita, C. et al. Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia. Leukemia 28, 1545–1548 (2014). https://doi.org/10.1038/leu.2014.58

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