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CXCR4 expression in CD34+ cells and unit predominance after double umbilical cord blood transplantation

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References

  1. Lapidot T, Dar A, Kollet O . How do stem cells find their way home? Blood 2005; 106: 1901–1910.

    Article  CAS  Google Scholar 

  2. Ohno N, Kajiume T, Sera Y, Sato T, Kobayashi M . Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression. Stem Cells Dev 2009; 18: 1221–1226.

    Article  CAS  Google Scholar 

  3. Timeus F, Crescenzio N, Basso G, Ramenghi U, Saracco P, Gabutti V . Cell adhesion molecule expression in cord blood CD34+ cells. Stem Cells 1998; 16: 120–126.

    Article  CAS  Google Scholar 

  4. Brunstein CG, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, Blazar BR et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood 2007; 110: 3064–3070.

    Article  CAS  Google Scholar 

  5. Gutman JA, Turtle CJ, Manley TJ, Heimfeld S, Bernstein ID, Riddell SR et al. Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood 2010; 115: 757–765.

    Article  CAS  Google Scholar 

  6. Scaradavou A, Smith KM, Hawke R, Schaible A, Abboud M, Kernan NA et al. Cord blood units with low CD34+ cell viability have a low probability of engraftment after double unit transplantation. Biol Blood Marrow Transplant 2010; 16: 500–508.

    Article  Google Scholar 

  7. Ramirez P, Wagner JE, Defor TE, Blazar BR, Verneris MR, Miller JS et al. Factors predicting single-unit predominance after double umbilical cord blood transplantation. Bone Marrow Transplant 2012; 47: 799–803.

    Article  CAS  Google Scholar 

  8. Kanda J, Rizzieri DA, Gasparetto C, Long GD, Chute JP, Sullivan KM et al. Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. Biol Blood Marrow Transplant 2011; 17: 867–874.

    Article  Google Scholar 

  9. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343–1347.

    Article  CAS  Google Scholar 

  10. Timeus F, Crescenzio N, Saracco P, Doria A, Fazio L, Albiani R et al. Recovery of cord blood hematopoietic progenitors after successive freezing and thawing procedures. Haematologica 2003; 88: 74–79.

    PubMed  Google Scholar 

  11. Broxmeyer HE . Chemokines in hematopoiesis. Curr Opin Hematol 2008; 15: 49–58.

    Article  CAS  Google Scholar 

  12. Ratajczak J, Reca R, Kucia M, Majka M, Allendorf DJ, Baran JT et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 2004; 103: 2071–2078.

    Article  CAS  Google Scholar 

  13. Hoggatt J, Singh P, Sampath J, Pelus LM . Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 2009; 113: 5444–5455.

    Article  CAS  Google Scholar 

  14. Cutler CS, Shoemaker D, Ballen KK, Robbins D, Desponts C, Kao GS et al. FT1050 (16,16-dimethyl Prostaglandin E2)-enhanced umbilical cord blood accelerates hematopoietic engraftment after reduced intensity conditioning and double umbilical cord blood transplantation. ASH Annu Meet Abstr 2011; 118: 653.

    Google Scholar 

  15. Brunstein CG, McKenna DH, DeFor TE, Sumstad D, Ratajczak M, Laughlin MJ et al. Priming of hematopoietic progenitor cells (HPC) with complement fragment 3A (C3A) to promote homing of umbilical cord blood (UCB): safety profile. Biol Blood Marrow Transplant 2012; 18: S210.

    Article  Google Scholar 

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Acknowledgements

This work was supported in part by grants from the National Cancer Institute CA65493 (JEW, JSM, CGB), the Children’s Cancer Research Fund (JEW, TED), the American Cancer Society Audrey Meyer Mars International Fellowship in Clinical Oncology (PR) and Pontificia Universidad Católica de Chile (PR), American Society of Blood and Marrow Transplantation Robert A Good New Investigator Award (CGB), and Leukemia and Lymphoma Society Scholar in Clinical Research Award (CGB).

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Authors and Affiliations

  1. Blood and Marrow Transplantation Program, University of Minnesota Medical Center, Minneapolis, MN, USA

    P Ramirez, J E Wagner, T E DeFor, C R Eide, J S Miller, D J Weisdorf & C G Brunstein

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  1. P Ramirez
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  2. J E Wagner
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  3. T E DeFor
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  4. C R Eide
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  5. J S Miller
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  6. D J Weisdorf
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  7. C G Brunstein
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Corresponding author

Correspondence to C G Brunstein.

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The authors declare no conflict of interest.

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Ramirez, P., Wagner, J., DeFor, T. et al. CXCR4 expression in CD34+ cells and unit predominance after double umbilical cord blood transplantation. Leukemia 27, 1181–1183 (2013). https://doi.org/10.1038/leu.2012.261

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