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High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes

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Acknowledgements

This work was supported by a Grant-in-Aid for Cancer Research, Research on Children and Families, Research on intractable diseases, Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan, and by Grants-in-Aid for Scientific Research (B, C) or Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We thank Drs Ryoji Hanada (Division of Hematology/Oncology, Saitama Children's Medical Center, Japan), Kazuko Hamamoto (Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Japan), Hideo Nakamura (Department of Internal Medicine, Koufudai Hospital, Nagasaki, Japan), Kazuma Ohyashiki (First Department of Internal Medicine, Division of Hematology, Tokyo Medical University, Japan), Ikuo Miura, Department of Internal Medicine (Division of Hematology and Oncology, St Marianna University School of Medicine, Japan), Keiki Kawakami (Division of Hematology, Suzuka General Hospital, Japan), Hiroshi Miwa (Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Japan), Takaharu Matsuyama (Division of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Japan) and Yasuhito Arai, PhD (Cancer Genome Project, National Cancer Center Research Institute, Tokyo, Japan) for providing samples and clinical data of patients with chromosomal 11p15 translocations. We also thank Mrs Shoko Sohma, Hisae Soga, Midori Furui, Mayumi Naito, Mayumi Nagase and Rie Eda for their excellent technical assistance.

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Authors and Affiliations

  1. Division of Blood Transfusion, Shimane University Hospital, Shimane, Japan

    T Taketani

  2. Department of Pediatrics, Shimane University School of Medicine, Shimane, Japan

    T Taketani, S Fukuda & S Yamaguchi

  3. Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan

    T Taki

  4. Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    T Nakamura

  5. Hematology Division, National Cancer Center Hospital, Tokyo, Japan

    Y Kobayashi

  6. Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

    E Ito

  7. Department of Hematology/Oncology, Gunma Children's Medical Center, Gunma, Japan. E-mail: hayashiy-tky@umin.ac.jp,

    Y Hayashi

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  1. T Taketani
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  2. T Taki
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Taketani, T., Taki, T., Nakamura, T. et al. High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes. Leukemia 24, 1975–1977 (2010). https://doi.org/10.1038/leu.2010.207

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