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A rapid, simple, and humane method for submandibular bleeding of mice using a lancet

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Lab Animal

Abstract

Methods for obtaining blood samples from mice tend to be difficult, inhumane, or both. The authors describe an inexpensive, disposable, single-use lancet for submandibular bleeding of mice that allows investigators to quickly draw 0.2–0.5 ml of blood without the use of anesthesia.

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Figure 1
Figure 2: (a) The Goldenrod animal bleeding lancet removed from the sterile wrapper.
Figure 3: (a) Positioning and poking the cheek with the lancet.
Figure 4
Figure 5

References

  1. Fox, J.G., Anderson, L.C., Lowe, F.M. & Quimby, F.Q. (eds.). Laboratory Animal Medicine 2nd Edn. (Elsevier Science, New York, 2002).

    Google Scholar 

  2. Bertani, S., Gantier, J.C., Chabaud, A. & Landau, I. Action of adrenalin on the circulation of the murine Plasmodium developing stages, in different blood compartments. Parasite 11(4), 343–350 (2004).

    Article  CAS  Google Scholar 

  3. Fields, B.T. & Cunnigham, D.R. A tail artery technique for collecting one-half milliliter of blood from a mouse. Lab Anim. Sci. 26(3), 505–506 (1976).

    PubMed  Google Scholar 

  4. Hem, A., Smith, A.J. & Solberg, P. Saphenous vein puncture for blood sampling of the mouse, rat, gerbil, guinea pig, ferret and mink. Lab. Anim. 32(4), 364–368 (1998).

    Article  CAS  Google Scholar 

  5. Hoff, J. Methods of blood collection in the mouse. Lab Anim. (NY) 29(10), 47–53 (2000).

    Google Scholar 

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Acknowledgements

Photos were provided by E. Clark.

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Authors and Affiliations

  1. Plum Island Animal Disease Center, ARS, USDA, Greenport, 11944, NY

    William T. Golde & Luis L. Rodriguez

  2. MediPoint Inc., Mineola, 11501, NY

    Peter Gollobin

Authors
  1. William T. Golde
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  2. Peter Gollobin
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  3. Luis L. Rodriguez
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Corresponding author

Correspondence to William T. Golde.

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Competing interests

All three authors are inventors of the patent-pending technology described here, and developed under a Cooperative Research and Development Agreement between the US Department of Agriculture, Agricultural Research Service and MEDIpoint, Inc.

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Golde, W., Gollobin, P. & Rodriguez, L. A rapid, simple, and humane method for submandibular bleeding of mice using a lancet. Lab Anim 34, 39–43 (2005). https://doi.org/10.1038/laban1005-39

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  • DOI: https://doi.org/10.1038/laban1005-39

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