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Improved technique for induction and monitoring of audiogenic seizure in deer mice

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Abstract

Epilepsy is a debilitating disease characterized by recurring seizures. Epilepsy can be studied using animal models, such as rodents prone to audiogenic seizure (AGS), which experience generalized seizures (loss of consciousness accompanied by rhythmic muscle spasms and rigid muscle stiffness) after intense sound stimulation. In 1933, a spontaneous mutation resulting in sensitivity to AGS was observed among laboratory stocks of deer mice (Peromyscus maniculatus artemisiae) at the University of Michigan. Since then, AGS-sensitive deer mice have been maintained as a separate stock, currently housed at the Peromyscus Genetic Stock Center. To further characterize AGS, the authors designed reliable and consistent equipment for inducing and monitoring AGS in deer mice.

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Figure 1: Still image from a video recording of AGS sensitivity testing in a deer mouse using a conventional wire cage testing chamber.
Figure 2
Figure 3: Still image from a video recording of AGS sensitivity testing in a deer mouse using our improved equipment.
Figure 4: Elapsed time to clonus in deer mice tested using a conventional chamber (green points) or using our new testing chamber (red points).

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Authors and Affiliations

  1. Department of Biological Sciences, Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC

    Monika Veres, Susan Payne,  Janet P. Crossland &  Gabor Szalai

  2. Division of Science, Math & Engineering, University of South Carolina Sumter, Sumter, SC

    Pearl Fernandes

Authors
  1. Monika Veres
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  2. Susan Payne
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  3. Pearl Fernandes
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  4. Janet P. Crossland
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  5. Gabor Szalai
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Correspondence to Gabor Szalai.

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The authors declare no competing financial interests.

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Veres, M., Payne, S., Fernandes, P. et al. Improved technique for induction and monitoring of audiogenic seizure in deer mice. Lab Anim 42, 166–169 (2013). https://doi.org/10.1038/laban.263

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  • DOI: https://doi.org/10.1038/laban.263

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