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‘Haptoglobin concentrations in preterm and term newborns’

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Abstract

Objective:

To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns.

Study Design:

HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon–Mann–Whitney test was used for comparisons.

Result:

HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033).

Conclusion:

HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis.

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Acknowledgements

We thank Dr Kris Sekar for his thoughtful review and valuable comments to this manuscript, and Chee Yoon S Bauer for technical assistance with laboratory assays. We gratefully acknowledge the support of the Children's Medical Research Institute.

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Authors and Affiliations

  1. Department of Pediatrics, Section of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma city, OK, USA

    S Chavez-Bueno, J A Beasley, J M Goldbeck, B C Bright, D J Morton, P W Whitby & T L Stull

  2. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma city, OK, USA

    D J Morton, P W Whitby & T L Stull

  3. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma city, OK, USA

    B C Bright

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  1. S Chavez-Bueno
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  2. J A Beasley
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Correspondence to S Chavez-Bueno.

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Chavez-Bueno, S., Beasley, J., Goldbeck, J. et al. ‘Haptoglobin concentrations in preterm and term newborns’. J Perinatol 31, 500–503 (2011). https://doi.org/10.1038/jp.2010.197

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  • DOI: https://doi.org/10.1038/jp.2010.197

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