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Perinatal/Neonatal Case Presentation

Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy

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Abstract

We report a case study of a 22-year-old woman with mitochondrial thymidine kinase 2 deficiency and chronic respiratory failure due to severe neuromuscular weakness requiring noninvasive positive pressure ventilation (NIPPV) since 12 years of age. During pregnancy and cesarean delivery, she was successfully supported with NIPPV. A multidisciplinary team approach should be used in pregnant patients with these disorders with specific attention to management of pulmonary complications, selection of route of delivery, anesthesia, and analgesia.

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Acknowledgements

No financial support was received.

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Authors and Affiliations

  1. Department of Pediatrics, Center of Excellence in Pulmonary Biology (Pulmonary Division), Stanford University Medical Center, Palo Alto, CA, USA

    N Yuan & T E Robinson

  2. Division of Maternal-Fetal Medicine, Lucile Packard Children's Hospital, Palo Alto, CA, USA

    Y Y El-Sayed

  3. Department of Pulmonary and Critical Care Medicine, Stanford University, Palo Alto, CA, USA

    S J Ruoss

  4. Department of Anesthesia, Stanford University, Palo Alto, CA, USA

    E Riley

  5. Division of Medical Genetics, Lucile Packard Children's Hospital, Palo Alto, CA, USA

    G M Enns

Authors
  1. N Yuan
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  2. Y Y El-Sayed
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  3. S J Ruoss
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  4. E Riley
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  5. G M Enns
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  6. T E Robinson
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Correspondence to N Yuan.

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Yuan, N., El-Sayed, Y., Ruoss, S. et al. Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy. J Perinatol 29, 166–167 (2009). https://doi.org/10.1038/jp.2008.178

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  • DOI: https://doi.org/10.1038/jp.2008.178

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