Abstract
Objective:
To compare feeding tolerance, nutrient intake and growth in preterm infants (⩽32 weeks, ⩽1750 g) fed either a standard nonhydrolyzed whey–casein (nHWC) or a partially hydrolyzed whey (pHW) preterm infant formula.
Study Design:
In this double-blind randomized controlled trial infants were fed either formula for at least 3 weeks. Intake was monitored daily, serum chemistries and growth weekly. Data were analyzed using analysis of covariance.
Result:
A total of 80 infants were enrolled, 72 completed the study. No differences were noted in demographic characteristics. No differences were detected in feeding tolerance, intakes (118±21 vs 119±14; nHWC vs pHW) or growth weight, 28±1.5 vs 28±1.6 g per day; length, 1.0±0.7 vs 1.0±0.6 cm per week; head circumference, 0.9±0.4 vs 1.0±0.44 cm per week). At the end of study, blood urea nitrogen (5.2±3.1 <6.7±2.3 mg per 100 ml, nHWC<pHW), total serum proteins (4.7±0.4 >4.4±0.5 g per 100 ml) and albumin (2.7±0.3 >2.6±0.4 g per 100 ml) differed.
Conclusion:
A pHW preterm infant formula was not associated with improved feeding tolerance, enteral intake or growth but differences in serum chemistries. These are unlikely to be clinically relevant because values were well within normal limits for preterm infants, whereas growth was identical in both groups and paralleled that ‘in utero’.
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Acknowledgements
We thank the nursing and medical staff at the Newborn Center, University of Tennessee Center for Health Sciences, Memphis, TN for their support in this study. We also thank Dr C Hager, Nestec Ltd., Vevey, Switzerland for statistical expertise in analyzing the data. This study was supported by a grant from Nestec Ltd., Vevey, Switzerland. This study was supported by a grant from Nestec Ltd., Vevey, Switzerland.
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Florendo, K., Bellflower, B., van Zwol, A. et al. Growth in preterm infants fed either a partially hydrolyzed whey or an intact casein/whey preterm infant formula. J Perinatol 29, 106–111 (2009). https://doi.org/10.1038/jp.2008.124
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DOI: https://doi.org/10.1038/jp.2008.124
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