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Response to 'Challenge in interpretation of Mendelian randomization studies using lactase persistence as instrumental variable'

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References

  1. Yang Q, Lin SL, Au Yeung SL, Kwok MK, Xu L, Leung GM et al. Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr 2017, e-pub ahead of print 22 February 2017 doi:10.1038/ejcn.2017.8.

    Article  CAS  Google Scholar 

  2. Del Greco MF, Foco L, Pichler I, Eller P, Eller K, Benyamin B et al. Serum iron level and kidney function: a Mendelian randomization study. Nephrol Dial Transplant 2017; 32: 273–278.

    Google Scholar 

  3. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G . Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008; 27: 1133–1163.

    Article  Google Scholar 

  4. Lomer MC, Parkes GC, Sanderson JD . Review article: lactose intolerance in clinical practice–myths and realities. Aliment Pharmacol Ther 2008; 27: 93–103.

    Article  CAS  Google Scholar 

  5. Bergholdt HK, Nordestgaard BG, Varbo A, Ellervik C . Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98,529 Danish adults. Int J Epidemiol 2015; 44: 587–603.

    Article  Google Scholar 

  6. Hartwig FP, Horta BL, Smith GD, de Mola CL, Victora CG . Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis. Int J Epidemiol 2016; 45: 1573–1587.

    Article  Google Scholar 

  7. Barr SI . Perceived lactose intolerance in adult Canadians: a national survey. Appl Physiol Nutr Metab 2013; 38: 830–835.

    Article  CAS  Google Scholar 

  8. Taylor AE, Davies NM, Ware JJ, VanderWeele T, Smith GD, Munafo MR . Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. Econ Hum Biol 2014; 13: 99–106.

    Article  Google Scholar 

  9. Smith GD, Lawlor DA, Timpson NJ, Baban J, Kiessling M, Day IN et al. Lactase persistence-related genetic variant: population substructure and health outcomes. Eur J Hum Genet 2009; 17: 357–367.

    Article  CAS  Google Scholar 

  10. Hollox EJ, Poulter M, Zvarik M, Ferak V, Krause A, Jenkins T et al. Lactase haplotype diversity in the Old World. Am J Hum Genet 2001; 68: 160–172.

    Article  CAS  Google Scholar 

  11. Thondamal M, Witting M, Schmitt-Kopplin P, Aguilaniu H . Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans Nat Commun 2014; 5: 4879.

    Article  CAS  Google Scholar 

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Correspondence to C M Schooling.

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Yang, Q., Schooling, C. Response to 'Challenge in interpretation of Mendelian randomization studies using lactase persistence as instrumental variable'. Eur J Clin Nutr 72, 181–182 (2018). https://doi.org/10.1038/ejcn.2017.119

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