Modification of messenger RNAs through a process called m6A methylation facilitates dynamic temporal regulation of RNA levels in neural precursor cells, enabling fine-tuning of developing neuronal circuits in the brain.
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References
Herculano-Houzel, S., Manger, P. R. & Kaas, J. H. Front. Neuroanat. 8, 77 (2014).
Yoon, K. et al. Cell 171, 877–889 (2017).
Li, X., Xiong, X. & Yi, C. Nature Methods 14, 23–31 (2016).
Zhao, B. S., Roundtree, I. A. & He, C. Nature Rev. Mol. Cell Biol. 18, 31–42 (2017).
Desrosiers, R. C., Friderici, K. H. & Rottman, F. M. Biochemistry 14, 4367–4374 (1975).
Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).
Patil, D. P. et al. Nature 537, 369–373 (2016).
Wang, Y. et al. Nature Cell Biol. 16, 191–198 (2014).
Batista, P. J. et al. Cell Stem Cell 15, 707–719 (2014).
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S. & Kriegstein, A. R. Nature 409, 714–720 (2001).
Breunig, J. J., Haydar, T. F. & Rakic, P. Neuron 70, 614–625 (2011).
Taverna, E., Götz, M. & Huttner, W. B. Annu. Rev. Cell Dev. Biol. 30, 465–502 (2014).
Leighton, L. J. et al. Genes Brain Behav. https://doi.org/10.1111/gbb.12426 (2017).
Widagdo, J. et al. J. Neurosci. 36, 6771–6777 (2016).
Sweatt, J. D. Neuron 80, 624–632 (2013).
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Sweatt, J. Layered-up regulation in the developing brain. Nature 551, 448–449 (2017). https://doi.org/10.1038/d41586-017-07269-7
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DOI: https://doi.org/10.1038/d41586-017-07269-7
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