References
Vavassori S, Kumar A, Wan GS, Ramanjaneyulu GS, Cavallari M, El Daker S et al. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nat Immunol 2013; 14: 908–916.
Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S . Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 1984; 309: 757–762.
Hayday AC . Gammadelta T cells and the lymphoid stress-surveillance response. Immunity 2009; 31: 184–196.
Vantourout P, Hayday A . Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol 2013; 13: 88–100.
Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL . γδ T cells: an important source of IL-17. Curr Opin Immunol 2008; 20: 353–357.
Holtmeier W, Kabelitz D . γδ T cells link innate and adaptive immune responses. Chem Immunol Allergy 2005; 86: 151–183.
Strid J, Tigelaar RE, Hayday AC . Skin immune surveillance by T cells—a new order? Semin Immunol 2009; 21: 110–120.
Björkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC . Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987; 329: 506–512.
Chang WC, Song H, Liu HW, Liu P . Current development in isoprenoid precursor biosynthesis and regulation. Curr Opin Chem Biol 2013; 17: 571–579.
Kistowska M, Rossy E, Sansano S, Gober HJ, Landmann R, Mori L et al. Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. Eur J Immunol 2008; 38: 2200–2209.
Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK et al. Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Int Immunol 2007; 19: 657–673.
Eberl M, Hintz M, Reichenberg A, Kollas AK, Wiesner J, Jomaa H . Microbial isoprenoid biosynthesis and human γδ T cell activation. FEBS Lett 2003; 544: 4–10.
Laggner U, Di Meglio P, Perera GK, Hundhausen C Lacy KE, Ali N et al. Identification of a novel proinflammatory human skin-homing Vgamma9Vdelta2 T cell subset with a potential role in psoriasis. J Immunol 2011; 187: 2783–2793.
Alaibac M, Harms G, Zwingenberger K, Morris J, Yu R, Chu AC . γδ T lymphocytes in oriental cutaneous leishmaniasis: occurrence and variable delta gene expression. Br J Dermatol 1993; 128: 388–392.
Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J et al. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood 2012; 120: 2269–2279.
Wang H, Henry O, Distefano MD, Peigné CM, Mönkkönen H, Mönkkönen J et al. Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vgamma2Vdelta2 T cells. J Immunol 2013; 191: 1029–1042.
Afrache H, Gouret P, Ainouche S, Pontarotti P, Olive D . The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response. Immunogenetics 2012; 64: 781–794.
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The research of CE is supported by grants from the Deutsche Forschungsgemeinschaft (DFG ES103/5-1 and 103/6-1).
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Esser, C. A fat story—antigen presentation by butyrophilin 3A1 to γδ T cells. Cell Mol Immunol 11, 5–7 (2014). https://doi.org/10.1038/cmi.2013.46
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DOI: https://doi.org/10.1038/cmi.2013.46
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