Skip to main content

Advertisement

SpringerLink
Log in

The activity of hematopoietic stem cell transplantation in Korea

  • Review
  • Published:
Bone Marrow Transplantation Submit manuscript

Abstract

Since the first successful allogeneic hematopoietic SCT (HSCT) was performed in Korea in 1983, there has been a noticeable progress in both the quantity and quality of HSCT over 24 years. There are 38 HSCT centers in Korea and the number of both allogeneic and autologous HSCTs has been increasing every year. As of December 2006, a total of 9561 HSCTs have been carried out in Korea, including 5617 allogeneic (59%) and 3944 autologous HSCTs (41%). The main indications were acute leukemia (3979, 78% allogeneic); lymphoma (1244, 90% autologous); myeloma (939, 92% autologous) and aplastic anemia (938). Characteristically, severe aplastic anemia accounts for a considerable proportion of transplants (10%), compared with western countries. Recently, there has been a marked increase in the number of unrelated transplants and the usage of PBSCs. The pattern of infectious diseases associated with HSCT is quite different. The rapid expansion of unrelated donor pools worldwide has changed the outlook of an unrelated donor search in Korea.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. Copelan EA . Hematopoietic stem-cell transplantation. N Engl J Med 2006; 354: 1813–1826.

    Article  CAS  Google Scholar 

  2. Ljungman P, Urbano-Ispizua A, Cavazzana-Calvo M, Demirer T, Dini G, Einsele H et al., European Group for Blood Marrow. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 2006; 37: 439–449.

    Article  CAS  Google Scholar 

  3. Thomas ED . Bone marrow transplantation: a review. Semin Hematol 1999; 36 (Suppl 7): 95–103.

    CAS  PubMed  Google Scholar 

  4. Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM . Bone-marrow transplantation in a patient with the Wiskott–Aldrich syndrome. Lancet 1968; 2: 1364–1366.

    Article  CAS  Google Scholar 

  5. Kim DJ, Kim CC, Kim BK, Kim DW, Lee JW, Jin JY et al. Allogeneic bone marrow transplantation in Korea: 1983–1992. Bone Marrow Transplant 1994; 13: 717–719.

    CAS  PubMed  Google Scholar 

  6. Gratwohl A, Baldomero H, Frauendorfer K, Urbano-Ispizua A, Niederwieser D . Results of the EBMT activity survey 2005 on haematopoietic stem cell transplantation: focus on increasing use of unrelated donors. Bone Marrow Transplant 2007; 39: 71–87.

    Article  CAS  Google Scholar 

  7. Gratwohl A, Baldomero H, Schmid O, Horisberger B, Bargetzi M, Urbano-Ispizua A . Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003. Bone Marrow Transplant 2005; 36: 575–590.

    Article  CAS  Google Scholar 

  8. Lee KH, Choi SJ, Lee JH, Lee JS, Kim WK, Lee KB et al. Prognostic factors identifiable at the time of onset of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation. Haematologica 2005; 90: 939–948.

    PubMed  Google Scholar 

  9. Oh H, Loberiza Jr FR, Zhang MJ, Ringdén O, Akiyama H, Asai T et al. Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations. Blood 2005; 105: 1408–1416.

    Article  CAS  Google Scholar 

  10. Yoo JH, Lee DG, Choi SM, Choi JH, Park YH, Kim YJ et al. Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea. Bone Marrow Transplant 2004; 34: 497–504.

    Article  Google Scholar 

  11. Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW et al. Current trends of infectious complications following hematopoietic stem cell transplantation in a single center. J Korean Med Sci 2006; 21: 199–207.

    Article  Google Scholar 

  12. Lee J, Lee MH, Kim WS, Kim K, Park SH, Lee SH et al. Tuberculosis in hematopoietic stem cell transplant recipients in Korea. Int J Hematol 2004; 79: 185–188.

    Article  Google Scholar 

  13. Choi SM, Lee DG, Choi JH, Yoo JH, Kim YJ, Park SH et al. Risk-adapted preemptive therapy for cytomegalovirus disease after allogeneic stem cell transplantation: a single-center experience in Korea. Int J Hematol 2005; 81: 69–74.

    Article  Google Scholar 

Download references

Acknowledgements

We thank staff of Korean Society of Blood and Marrow Transplantation for cooperation. We also thank Korean HSCT Nurses' Society for data collection.

Author information

Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Catholic Hematopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul, Korea

    J-W Lee & C-C Kim

Authors
  1. J-W Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C-C Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J-W Lee.

Additional information

Conflict of interest

Neither author declared any financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, JW., Kim, CC. The activity of hematopoietic stem cell transplantation in Korea. Bone Marrow Transplant 42 (Suppl 1), S92–S95 (2008). https://doi.org/10.1038/bmt.2008.127

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2008.127

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation