Abstract
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
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Taylor, G., Dearden, S., Payne, N. et al. Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility in childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. Br J Cancer 78, 561–565 (1998). https://doi.org/10.1038/bjc.1998.540
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DOI: https://doi.org/10.1038/bjc.1998.540
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