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Experience with poorly myelosuppressive chemotherapy schedules for advanced myeloma

  • Experimental Oncology
  • Published:
British Journal of Cancer Submit manuscript

Abstract

In a multicentre study, 83 patients with advanced and previously uniformly treated multiple myeloma (MM) were randomised between cyclophosphamide (600 mg m-2) and epirubicin (70 mg m-2), administered every 3 weeks for three courses and both associated with prednisone and interferon-alpha2b. Both regimens were administered on an outpatient basis and had low haematological toxicity. Clinical results were similar. Overall response rate (43%) and median response and survival (5.9 and 14.1 months respectively) compare well with those obtained with more aggressive chemotherapy schedules.

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Authors and Affiliations

  1. Medicina Interna ed Oncologia Medica, Universita and Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, Pavia, Italy

    S Brugnatelli

Authors
  1. S Brugnatelli
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  2. A Riccardi
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  3. G Ucci
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  4. O Mora
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  5. L Barbarano
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  6. N Piva
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  7. L Piccinini
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  8. C Bergonzi
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  9. A De Paoli
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  10. M Di Stasi
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  11. E Rinaldi
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  12. G Trotti
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  13. M Petrini
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  14. E Ascari
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(for the Cooperative Group of Study and Treatment of Multiple Myeloma)

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Brugnatelli, S., Riccardi, A., Ucci, G. et al. Experience with poorly myelosuppressive chemotherapy schedules for advanced myeloma. Br J Cancer 73, 794–797 (1996). https://doi.org/10.1038/bjc.1996.138

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  • DOI: https://doi.org/10.1038/bjc.1996.138

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