Abstract
The effect of photodynamic therapy (PDT) on interstitial fluid pressure (IFP), tumour volume and water content was measured in melanomas grown in hamsters. Unlike control tumours, treated tumours exhibited a 40-60% increase in volume at 1, 3 and 6 h post PDT. IFP also increased at 1 and 3 h after PDT, but decreased to 50% of control value after 24 h, presumably as a result of PDT-induced microcirculatory impairment.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leunig, M., Goetz, A., Gamarra, F. et al. Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. Br J Cancer 69, 101–103 (1994). https://doi.org/10.1038/bjc.1994.15
Issue Date:
DOI: https://doi.org/10.1038/bjc.1994.15
- Springer Nature Limited
This article is cited by
-
1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors
Annals of Biomedical Engineering (1996)