Abstract
The phenotype of peripheral blood lymphocytes of 27 renal cell carcinoma patients before and at the end of subcutaneously given rIL-2 therapy was determined by two colour flow cytometry. Therapy induced changes in peripheral blood leucocyte composition and phenotypes were comparable to those reported for intravenously given rIL-2. The present paper shows a correlation between the 'activation status' of the patient before therapy and eventual response.
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Janssen, R., Sleijfer, D., Heijn, A. et al. Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma. Br J Cancer 66, 1177–1179 (1992). https://doi.org/10.1038/bjc.1992.431
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DOI: https://doi.org/10.1038/bjc.1992.431
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