Abstract
The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro has been compared. The tumour cell line was much more sensitive to the cytotoxic action of the three agents compared to the CHO cell line. CHIP and carboplatin gave similar dose-response curves, both being much less toxic than cis-platin. The effect of thiol modification on platinum toxicity was also investigated. Substantial reduction in the intracellular non-protein sulphydryl content markedly enhanced the cytotoxicity of CHIP but had much less effect on carboplatin and cis-platin. Thiol depletion by diethylmaleate had a negligible effect on cis-platin toxicity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Smith, E., Brock, A. An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion. Br J Cancer 57, 548–552 (1988). https://doi.org/10.1038/bjc.1988.126
Issue Date:
DOI: https://doi.org/10.1038/bjc.1988.126
- Springer Nature Limited
This article is cited by
-
Allantoin reduces cell death induced by cisplatin: possible implications for tumor lysis syndrome management
JBIC Journal of Biological Inorganic Chemistry (2019)
-
Intracellular glutathione and cytotoxicity of platinum complexes
Cancer Chemotherapy and Pharmacology (1995)
-
The relative nephrotoxicity of cisplatin,cis-[Pt(NH3)2(guanosine)2]2+, and the hydrolysis product of cisplatin in the rat
Cancer Chemotherapy and Pharmacology (1991)