Abstract
During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumours over successive transplant generations. These sarcomas had growth rates, tumour karyotypes and isoenzyme patterns which clearly distinguished them from the original human xenografts.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Sparrow, S., Jones, M., Billington, S. et al. The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts. Br J Cancer 53, 793–797 (1986). https://doi.org/10.1038/bjc.1986.134
Issue Date:
DOI: https://doi.org/10.1038/bjc.1986.134
- Springer Nature Limited
This article is cited by
-
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Nature Communications (2021)
-
Transcriptional dissection of pancreatic tumors engrafted in mice
Genome Medicine (2014)
-
Human pontine glioma cells can induce murine tumors
Acta Neuropathologica (2014)
-
Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts
BMC Biotechnology (2011)
-
Different tumorigenicity of cell clones derived from stromal fibroblasts of human colon cancer xenografts
Bulletin of Experimental Biology and Medicine (1994)