Abstract
The response of multicellular tumour spheroids of the EMT6 cell line to combinations of hyperthermia and Bleomycin (BLM) or Adriamycin (ADM) has been investigated. Using this model system, we have demonstrated enhanced BLM cytotoxicity at 43 degrees C and also heat-induced drug tolerance to BLM at 43 degrees C. ADM cytotoxicity was not significantly increased after 43 degrees C x 1 h but after 6 h at 42 degrees C greatly enhanced cell-killing was evident. These results are discussed in relation to our previous data for EMT6 cells growing either as monolayer cultures in vitro or as solid tumours in mice.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Morgan, J., Bleehen, N. Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs. Br J Cancer 43, 384–391 (1981). https://doi.org/10.1038/bjc.1981.59
Issue Date:
DOI: https://doi.org/10.1038/bjc.1981.59
- Springer Nature Limited
This article is cited by
-
Effect of pH and moderate hyperthermia on doxorubicin, epirubicin and aclacinomycin A cytotoxicity for Chinese hamster ovary cells
Cancer Chemotherapy and Pharmacology (1993)
-
Hyperthermia in cancer therapy
European Journal of Pediatrics (1988)
-
Multicellular spheroids
Journal of Cancer Research and Clinical Oncology (1987)