Abstract
A late-gestation neonatal antigen (gamma foetal antigen, gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse.
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Higgins, P., Tong, C., Borenfreund, E. et al. Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen. Br J Cancer 40, 253–259 (1979). https://doi.org/10.1038/bjc.1979.173
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DOI: https://doi.org/10.1038/bjc.1979.173
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