Abstract
The inhibitory effect of the protease inhibitor aprotinin (Trasylol) on the invasion of mouse kidney explants by polyoma virus transformed BHK21 cells was investigated using a mixed cell/organ culture technique. The extent of invasion was monitored by following the changes in LDH isoenzyme pattern in the explants and by histological assessment. The kidney explants containing aprotinin were found to maintain a normal kidney LDH pattern and to suffer considerably less invasion than the explants not containing the drug. These results support the idea that proteolytic enzymes are associated with invasion and that inhibitors of protease activity could possibly be useful in the management of clinical cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Latner, A., Longstaff, E. & Pradhan, K. Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor. Br J Cancer 27, 460–464 (1973). https://doi.org/10.1038/bjc.1973.58
Issue Date:
DOI: https://doi.org/10.1038/bjc.1973.58
- Springer Nature Limited
This article is cited by
-
The Role of Perioperative Pharmacological Adjuncts in Cancer Outcomes: Beta-Adrenergic Receptor Antagonists, NSAIDs and Anti-fibrinolytics
Current Anesthesiology Reports (2015)
-
Adhesion molecules and their role in cancer metastasis
Cell Biophysics (1993)
-
Ascitic fluid ?1-antitrypsin
Digestive Diseases and Sciences (1990)
-
A multicenter trial of the use of the proteolytic enzyme inhibitor aprotinin in colorectal surgery
Diseases of the Colon & Rectum (1989)
-
The influence of the protease inhibitor aprotinin on tumor invasion of three cell linesin vitro
Clinical & Experimental Metastasis (1988)