Abstract
Walker carcinosarcoma cells cause in vitro osteolysis which may be inhibited by aspirin. In the rat, this tumour produces osteolytic bone deposits and hypercalcaemia, both of which can be prevented by aspirin and indomethacin, whereas soft tissue tumour deposits are unaffected by these drugs. Some human breast tumours cause in vitro osteolysis which may be inhibited by aspirin.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Powles, T., Clark, S., Easty, D. et al. The Inhibition by Aspirin and Indomethacin of Osteolytic Tumour Deposits and Hypercalcaemia in Rats with Walker Tumour, and its Possible Application to Human Breast Cancer. Br J Cancer 28, 316–321 (1973). https://doi.org/10.1038/bjc.1973.154
Issue Date:
DOI: https://doi.org/10.1038/bjc.1973.154
- Springer Nature Limited
This article is cited by
-
Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies
Cancer and Metastasis Reviews (2014)
-
Aspirin use and breast cancer risk: a meta-analysis
Breast Cancer Research and Treatment (2012)
-
Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?
British Journal of Cancer (2011)
-
Breast cancer metastasis to the bone: mechanisms of bone loss
Breast Cancer Research (2010)
-
Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
Breast Cancer Research (2006)