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Biological Effects of Corynebacterium Parvum. III. amplification of resistance and impairment of Active Immunity to Murine Tumours

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Abstract

The effect of pre-treatment with Corynebacterium parvum on the growth in vivo of a range of experimental mouse tumours with differing characteristics has been investigated. Varying degrees of protection were observed which were generally greater with the more immunogenic tumours. Administration of C. parvum 7 days before immunization with irradiated tumour cells diminished the protective effect which could be obtained by immunization alone. The possible basis for these seemingly conflicting influences is considered.

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Authors
  1. S E Smith
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  2. M T Scott
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Smith, S., Scott, M. Biological Effects of Corynebacterium Parvum. III. amplification of resistance and impairment of Active Immunity to Murine Tumours. Br J Cancer 26, 361–367 (1972). https://doi.org/10.1038/bjc.1972.47

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  • DOI: https://doi.org/10.1038/bjc.1972.47

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