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The Carcinogenicity of Two Diazadibenzopyrenes

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Abstract

1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive.

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Authors
  1. F Zajdela
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  2. N P Buu-Hoï
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  3. P Jacquignon
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  4. M Dufour
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Zajdela, F., Buu-Hoï, N., Jacquignon, P. et al. The Carcinogenicity of Two Diazadibenzopyrenes. Br J Cancer 26, 262–264 (1972). https://doi.org/10.1038/bjc.1972.35

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  • DOI: https://doi.org/10.1038/bjc.1972.35

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