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The NOD mouse model of type 1 diabetes: As good as it gets?

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Abstract

Of the two well-known rodent models of human type 1 diabetes (the non-obese diabetic mouse and the BioBreeding rat) the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both strengths and weaknesses.

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Figure 1: Insulitis in humans and NOD mouse pancreas.

References

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Authors and Affiliations

  1. Department of Pathology, University of Florida College of Medicine, Gainesville, 32610, Florida, USA

    Mark A. Atkinson

  2. The Jackson Laboratory, Bar Harbor, Maine , 04609, USA

    Edward H. Leiter

Authors
  1. Mark A. Atkinson
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  2. Edward H. Leiter
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Atkinson, M., Leiter, E. The NOD mouse model of type 1 diabetes: As good as it gets?. Nat Med 5, 601–604 (1999). https://doi.org/10.1038/9442

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