Identification of SH2D1A as the defective gene in X-linked lymphoproliferative syndrome highlighted the importance of SAP in the regulation of T cell activation. New data suggest an alternative explanation for how SAP controls signaling.
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Bob Crimi
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Nichols, K., Koretzky, G. & June, C. SAP: natural inhibitor or grand SLAM of T cell activation?. Nat Immunol 2, 665–666 (2001). https://doi.org/10.1038/90595
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DOI: https://doi.org/10.1038/90595
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