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Implications of a fusion peptide structure

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The membrane-inserted structure of a synthetic fusion peptide of influenza virus hemagglutinin has been determined. Structures such as this will further our understanding of the roles of the fusion peptide and may provide a means to develop a systematic view for how fusion peptide mutations in hemagglutinin affect the membrane fusion process.

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Figure 1: The sequence of the HA conformational changes that are coupled to membrane fusion.

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Authors and Affiliations

  1. the Department of Molecular Biophysics and Physiology, Rush Medical College, 1653 W. Congress Parkway, Chicago, 60612, Illinois, USA

    Fredric S. Cohen & Grigory B. Melikyan

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  1. Fredric S. Cohen
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  2. Grigory B. Melikyan
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Correspondence to Fredric S. Cohen.

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Cohen, F., Melikyan, G. Implications of a fusion peptide structure. Nat Struct Mol Biol 8, 653–655 (2001). https://doi.org/10.1038/90341

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