Skip to main content
SpringerLink
Log in

Finding the function buried in SAND

  • News & Views
  • Published:

From Nature Structural Biology

View current issue Submit your manuscript

The SAND domain is present in many proteins that have been linked to chromatin-dependent transcriptional regulation and human disease, but their function has remained unknown. Recent studies have revealed that these modules are DNA binding domains of novel molecular structure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: SAND domain contexts and functions.
Figure 2: Do SAND domains recognize the major groove in a manner reminiscent of the helix-turn-helix proteins?

References

  1. Bottomley, M.J. et al. Nature Struct. Biol. 8, 626–633 (2001).

    Article  CAS  Google Scholar 

  2. Gibson, T.J., Ramu, C., Gemund, C. & Aasland, R. Trends Biochem. Sci. 23, 242–244 (1998).

    Article  CAS  Google Scholar 

  3. Gross, C.T. & McGinnis, W. EMBO J. 15, 1961–1970 (1996).

    Article  CAS  Google Scholar 

  4. Huggenvik, J.I. et al. Mol. Endocrin. 12, 1619–1639 (1998).

    Article  CAS  Google Scholar 

  5. Christensen, J., Cotmore, S.F. & Tattersall, P. Mol. Cell. Biol. 19, 7741–7750 (1999).

    Article  CAS  Google Scholar 

  6. Bloch, D.B. et al. Mol. Cell. Biol. 20, 6138–6146 (2000).

    Article  CAS  Google Scholar 

  7. Bloch, D.B., Delamonte, S.M., Guigaouri, P., Filippov, A. & Bloch, K.D. J. Biol. Chem. 271, 29198–29204 (1996).

    Article  CAS  Google Scholar 

  8. Aaltonen, J. et al. Nature Genet. 17, 399–403 (1997).

    Article  Google Scholar 

  9. Michelson, R.J. et al. J. Biol. Chem. 274, 30510–30519 (1999).

    Article  CAS  Google Scholar 

  10. Smith, D.L. & Johnson, A.D. Cell 68, 133–142 (1992).

    Article  CAS  Google Scholar 

  11. Suzuki, M. & Brenner, S.E. FEBS Lett. 372, 215–221 (1995). (Published erratum appears in FEBS Lett. 381, 270, 1996).

    Article  CAS  Google Scholar 

  12. Wintjens, R. & Rooman, M. J. Mol. Biol. 262, 294–313 (1996).

    Article  CAS  Google Scholar 

  13. Oshima, H., Szapary, D. & Simons, S.S. J. Biol. Chem. 270, 21893–21901 (1995).

    Article  CAS  Google Scholar 

  14. Winston, F. & Allis, C.D. Nature Struct. Biol. 6, 601–604 (1999).

    Article  CAS  Google Scholar 

  15. Aasland, R., Gibson, T.J. & Stewart, A.F. Trends Biochem. Sci.s 20, 56–59 (1995).

    Article  CAS  Google Scholar 

  16. Seeler, J.S. et al. Mol. Cell. Biol. 21, 3314–3324 (2001).

    Article  CAS  Google Scholar 

  17. Sugihara, T.M., Bach, I., Kioussi, C., Rosenfeld, M.G. & Andersen, B. Proc. Natl. Acad. Sci. USA 95, 15418–15423 (1998).

    Article  CAS  Google Scholar 

  18. Seeler, J.S., Marchio, A., Sitterlin, D., Transy, C. & Dejean, A. Proc. Natl. Acad. Sci. USA 95, 7316–7321 (1998).

    Article  CAS  Google Scholar 

  19. Lehming, N., LeSaux, A., Schuller, J. & Ptashne, M. Proc. Natl. Acad. Sci. USA 95, 7322–7326 (1998).

    Article  CAS  Google Scholar 

  20. Lutterbach, B., Sun, D.X., Schuetz, J. & Hiebert, S.W. Mol. Cell. Biol. 18, 3604–3611 (1998).

    Article  CAS  Google Scholar 

  21. Schultz, S.C., Shields, G.C. & Steitz, T.A. Science 253, 1001–1007 (1991).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

J.M.W. and R.T.C. are supported by grants from the National Institutes of Health and Department of Energy.

Author information

Authors and Affiliations

  1. the Department of Chemistry and Biochemistry, Molecular Biology Institute and the UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, 90095-1570, California, USA

    Jonathan M. Wojciak & Robert T. Clubb

Authors
  1. Jonathan M. Wojciak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert T. Clubb
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert T. Clubb.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wojciak, J., Clubb, R. Finding the function buried in SAND. Nat Struct Mol Biol 8, 568–570 (2001). https://doi.org/10.1038/89582

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/89582

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation