Multiple error-prone DNA polymerase appear to contribute to immunoglobulin somatic hypermutation. Genetic and biochemical data now indicate that DNA polymerase η may be responsible for the generation of some of the strand-biased hotspot A mutations in the immunoglobulin loci.
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Storb, U. DNA polymerases in immunity: profiting from errors. Nat Immunol 2, 484–485 (2001). https://doi.org/10.1038/88673
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DOI: https://doi.org/10.1038/88673
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