Protein polymerization via 3D domain swapping has been suggested to promote amyloid plaque formation. Two recent papers provide support for a role for domain swapping in the formation of highly ordered aggregates such as the fibrils characteristic of amyloid plaques.
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Newcomer, M. Trading places. Nat Struct Mol Biol 8, 282–284 (2001). https://doi.org/10.1038/86134
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DOI: https://doi.org/10.1038/86134
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