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The early days of DNA sequences

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Abstract

Fred Sanger was awarded the rare distinction of two Nobel Prizes for Chemistry, in 1958 and 1980. The first was for his work on the structure of proteins, particularly that of insulin, the latter for his contribution concerning the determination of nucleic acid sequences, the foundation work that ultimately led to The Human Genome Project.

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References

  1. Wu, R. & Kaiser, A.D. Structure and base sequence in the cohesive ends of bacteriophage lambda DNA. J. Mol. Biol. 35, 523–527 (1968).

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  2. Gronenborn, B. & Messing, J. Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites. Nature 272, 375–377 (1978).

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Authors and Affiliations

  1. Head of Protein & Nucleic Acid Chemistry Medical Research Council Laboratory of Molecular Biology, Hills Rd, Cambridge

    Fred Sanger

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  1. Fred Sanger
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Sanger, F. The early days of DNA sequences. Nat Med 7, 267–268 (2001). https://doi.org/10.1038/85389

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