Skip to main content

Advertisement

SpringerLink
Log in

From angiogenesis to lymphangiogenesis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Vascular endothelial growth factors are well-known angiogenic agents and targets for anti-cancer therapies. Now it appears that this signaling pathway is also involved in developmental and tumor-induced lymphangiogenesis (pages 186-191, 192-198, 199-205).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Dissecting tumor angiogenesis. Hypoxic tumor cells produce VEGF , which binds to and activates VEGFR-2 on vascular endothelial cells, leading to classical tumor angiogenesis.

Stephen Horwitz

References

  1. Thun M.J. & Wingo P.A. in Cancer Medicine 5th Edition (eds. Bast, R.C. Jr. et al.) 283–297 (B.C. Becker, Hamilton, Ontario, Canada, 2000).

    Google Scholar 

  2. Cotran, R.S., Kumar, V. & Collins T. Pathologic basis of disease. 6th Edition. (W.B. Saunders, Philadelphia, Pennsylvania, 1999).

    Google Scholar 

  3. Mäkinen, T. et al. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nature Med. 7, 199–205 (2001).

    Article  Google Scholar 

  4. Skobe, M. et al. Induction of tumor lymphangiogenesis by vascular endothelial growth factor-C promotes breast cancer metastasis. Nature Med. 7, 192–198 (2001).

    Article  CAS  Google Scholar 

  5. Stacker, S.A. et al. Vascular endothelial growth factor-D promotes the metastatic spread of tumors via the lymphatics. Nature Med. 7, 186–191 (2001).

    Article  CAS  Google Scholar 

  6. Mandriota, S.J. et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumor metastasis. EMBO J. (in the press).

  7. Ferrara, N. & Hetzel, W.J. Pituitary follicular cells secrete a novel heparin binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Comm. 161, 851–858 (1989).

    Article  CAS  Google Scholar 

  8. Risau, W. Mechanisms of angiogenesis. Nature 386, 671–674, (1997).

    Article  CAS  Google Scholar 

  9. McMahon, G. VEGF receptor signaling in tumor angiogenesis. The Oncologist 5, s3–s10 (2000).

    Article  Google Scholar 

  10. Kaipanen, A. et al. Expression of the Fms-Like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. USA 92, 3566–3570 (1995).

    Article  Google Scholar 

  11. Joukov, V. et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15, 290–298 (1996).

    Article  CAS  Google Scholar 

  12. Achen, M.G. et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt-4). Proc. Natl. Acad. Sci. USA 95, 584–553 (1998).

    Article  Google Scholar 

  13. Banerji, S. et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144, 789–801 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuropathology Institute of Pathology, FAU, Erlangen-Nürnberg, Germany

    Karl H. Plate

Authors
  1. Karl H. Plate
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Plate, K. From angiogenesis to lymphangiogenesis. Nat Med 7, 151–152 (2001). https://doi.org/10.1038/84579

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/84579

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation