Studies in three different transgenic mouse models suggest that the amyloid β-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid β-peptide fragment reduces learning and memory impairments in mice, and this approach may eventually be used to prevent and/or treat this disease in people.
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Younkin, S. Amyloid β vaccination: reduced plaques and improved cognition. Nat Med 7, 18–19 (2001). https://doi.org/10.1038/83929
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DOI: https://doi.org/10.1038/83929
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