Skip to main content
SpringerLink
Log in

p53 and p73: seeing double?

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53−/− cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A schematic representation of the gene structure of the different p53 family members.
Figure 2: E2F1 can act as a tumour suppressor or as an oncogene.

References

  1. Giaccia, A.J. & Kastan, M.B. Genes Dev. 12, 2973–2983 (1998).

    Article  CAS  Google Scholar 

  2. Caspari, T. Curr. Biol. 10, R315–317 (2000).

    Article  CAS  Google Scholar 

  3. Stiewe, T. & Pützer, B.M. Nature Genet. 26, 464–469 ( 2000).

    Article  CAS  Google Scholar 

  4. Lissy, N.A., Davis, P.K., Irwin, M., Kaelin, W.G. Jr & Dowdy, S.F. Nature 407, 642–645 (2000).

    Article  CAS  Google Scholar 

  5. Irwin, M. et al. Nature 407, 645–648 (2000).

    Article  CAS  Google Scholar 

  6. Kaelin, W.G. Jr Oncogene 18, 7701–7705 ( 1999).

    Article  CAS  Google Scholar 

  7. Lohrum, M.A. & Vousden, K.H. Trends Cell Biol. 10, 197–202 ( 2000).

    Article  CAS  Google Scholar 

  8. Yang, A. et al. Nature 404, 99–103 (2000).

    Article  CAS  Google Scholar 

  9. Ikawa, S., Nakagawara, A. & Ikawa, Y. Cell Death Differ. 6, 1154– 1161 (1999).

    Article  CAS  Google Scholar 

  10. Sherr, C.J. &. Weber, J.D. Curr. Opin. Genet. Dev. 10, 94–99 ( 2000).

    Article  CAS  Google Scholar 

  11. Yamasaki, L. et al. Cell 85, 537–548 (1996).

    Article  CAS  Google Scholar 

  12. Schmitt, C.A. & Lowe, S.W. J. Pathol. 187, 127–137 (1999).

    Article  CAS  Google Scholar 

  13. Di Como, C.J. Gaiddon, C. & Prives, C. Mol. Cell. Biol. 19, 1438– 1449 (1999).

    Article  CAS  Google Scholar 

  14. Marin, M.C. et al. Nature Genet. 25, 47– 54 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    María S Soengas & Scott W Lowe

Authors
  1. María S Soengas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott W Lowe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soengas, M., Lowe, S. p53 and p73: seeing double?. Nat Genet 26, 391–392 (2000). https://doi.org/10.1038/82497

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/82497

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation