Hypoxia-inducible factor (HIF) is a key transcriptional regulator of the cellular response to hypoxia that is upregulated in many common cancers. Blockade of the pathway may provide a new opportunity for the development of cancer therapeutics (pages 1335-1340).
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Steve Horwitz
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Ratcliffe, P., Pugh, C. & Maxwell, P. Targeting tumors through the HIF system. Nat Med 6, 1315–1316 (2000). https://doi.org/10.1038/82113
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DOI: https://doi.org/10.1038/82113
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