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Cytokines, virokines and the evolution of immunity

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In a new twist, the cytokine IL-10, if present when leukocytes are activated, can disconnect chemokine receptors from signaling for cell migration. The receptors act as a “sink” for soaking up chemokines, thus providing the perfect decoy.

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Figure 1: Mechanisms of cytokine antagonism.

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Dower, S. Cytokines, virokines and the evolution of immunity. Nat Immunol 1, 367–368 (2000). https://doi.org/10.1038/80799

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