Combination therapies involving inhibitors of the epidermal growth factor and cyclooxygenase signaling prevent colorectal adenomas in mice. This synergistic effect may be due to the convergance of these two signaling pathways (pages 1024–1028).
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References
Torrance, et al. Combinatorial chemoprevention of intestinal neoplasia using an NSAID and an EGFR-kinase inhibitor. Nature Med. 6, 1024 –1028 (2000).
Steinbach, G. et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 342 , 1946–1952 (2000).
Pegram, M. et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J. Clin. Oncol. 16, 2659– 2671 (1998).
Kelloff, G. et al. Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives. Cancer Epidemiol. Biomarkers Prev. 5, 657–666 ( 1996).
Masferrer, J.L. et al. Antiangiogenic and antitumor activities of cyclooxygenase-2 Inhibitors. Cancer Res. 60, 1306– 1311 (2000).
Tsujii, M. et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705–716 (1998).
Williams, C.S., Tsujii, M., Reese, J., Dey, S.K. & DuBois, R.N. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 105, 1589–1594 (2000).
He, T.C., Chan, T.A., Vogelstein, B. & Kinzler, K.W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs . Cell 99, 335–345 (1999).
Feldman, A.M., Lorell, B.H. & Reis, S.E. Trastuzumab in the treatment of metastatic breast cancer: anticancer therapy versus cardiotoxicity. Circulation 102, 272–274 (2000).
Laine, L. et al. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 117 , 776–783 (1999).
Simon, L.S. et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. J. Am. Med. Assoc. 282, 1921–1928 (1999).
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Gupta, R., DuBois, R. Combinations for cancer prevention. Nat Med 6, 974–975 (2000). https://doi.org/10.1038/79664
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DOI: https://doi.org/10.1038/79664
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