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How many factors are required to remodel bone?

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Overexpression of two members of the AP-1 transcription factor family has dramatic effects on bone development, raising the question: why are there so many molecules that affect bone remodeling (pages 980–984 and 985–990)

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Figure 1: Two models can account for the effect of ΔFosB and Fra1 over-expression.

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Karsenty, G. How many factors are required to remodel bone?. Nat Med 6, 970–971 (2000). https://doi.org/10.1038/79655

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