Abstract
In 1989, Sidney Altman and Thomas R. Cech shared the Nobel Prize in Chemistry for their discovery of catalytic properties of RNA.
Cech was studying the splicing of RNA in a unicellular organism called Tetrahymena thermophila. He found that the precursor RNA could splice in vitro in the absence of proteins.
Altman studied ribonuclease P (RNase P), a ribonucleoprotein that is a key enzyme in the biosynthesis of tRNA. RNase P is an RNA processing endonuclease that specifically cleaves precursors of tRNA, releasing 5′ precursor sequences and mature tRNAs. RNase P is involved in processing all species of tRNA and is present in all cells and organelles that carry out tRNA synthesis.
What follows is a personal recollection by Altman of how he came to study this remarkable enzyme.
References
Abelson, J.N. et al. J.Mol.Biol. 47, 15–28 (1970).
Hirsh, D. J.Mol.Biol. 58, 439–458 (1971).
Crick, F.H.C. et al. Nature 192, 1227–1232 (1961).
Riddle, E.L. and Carbon, J. Nat. New Biol. 242, 230–234 (1973).
Altman, S. In Les Prix Nobel 1989. (Almqvist and Wiksell, Stockholm), 140–160 (1989).
Burdon, R.H. Prog. Nucl. Acids Res. Mol. Biol. 11, 33–79 (1971).
Bernhardt, D. and Darnell, J.E. J.Mol.Biol. 42, 43–56 (1967).
Altman, S. and Smith, J.D. Nat. New Biol. 233, 35–39 (1971).
Robertson, H.D. et al. J.Biol.Chem. 247, 5243–5251 (1972).
Altman, S. and Kirsebom, L.A. In The RNA world, eds. R.F. Gesteland, J.F. Alkins & T.R. Cech (Cold Spring Harbor, New York), Second edition, 351–380 (1999).
Smith, J.D. Brookhaven symposia in biology. 26. 1–11 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Altman, S. The road to RNase P. Nat Struct Mol Biol 7, 827–828 (2000). https://doi.org/10.1038/79566
Issue Date:
DOI: https://doi.org/10.1038/79566
- Springer Nature America, Inc.
This article is cited by
-
Development of a melting-curve based multiplex real-time PCR assay for simultaneous detection of Streptococcus agalactiae and genes encoding resistance to macrolides and lincosamides
BMC Pregnancy and Childbirth (2018)
-
A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks
Scientific Reports (2017)
-
Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production
Molecular Genetics and Genomics (2010)
-
Long-term RNase P-mediated inhibition of HIV-1 replication and pathogenesis
Gene Therapy (2001)