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Charting a course through RNA polymerase

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The known X-ray crystal structure of a bacterial RNA polymerase together with systematic site-specific protein nucleic acid crosslinking analyses have allowed the determination of the path of DNA and RNA through RNA polymerase.

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Figure 1: Schematic of the subunit structure of eukaryal RNAP I, II and III, the archaeal RNAP and bacterial core RNAP.
Figure 2: Representation of the path of DNA and RNA in the RNAP.

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Acknowledgements

We are grateful to R.H. Ebright for valuable discussions.

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Authors and Affiliations

  1. Wellcome Trust and Cancer Research Campaign Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK

    Stephen D. Bell & Stephen P. Jackson

  2. Department of Zoology, University of Cambridge, Cambridge, CB2, UK

    Stephen D. Bell & Stephen P. Jackson

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  1. Stephen D. Bell
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  2. Stephen P. Jackson
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Correspondence to Stephen D. Bell or Stephen P. Jackson.

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Bell, S., Jackson, S. Charting a course through RNA polymerase. Nat Struct Mol Biol 7, 703–705 (2000). https://doi.org/10.1038/78907

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