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Will radioiodine be useful in treatment of breast cancer?

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Expression of a sodium iodide transporter by the thyroid gland causes iodide accumulation, and radioactive iodide is an effective treatment for thyroid cancer. The identification of a similar transporter in mammary tissue indicates that this approach might also be used to treat breast cancer (pages 871–878).

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Figure 1: Reduced radioiodine uptake by a papillary thyroid carcinoma, compared to the surrounding normal gland.

References

  1. Marine, D. & Feiss, H.O. The absorption of potassium iodide by perfused thyroid glands and some of the factors modifying it. J. Pharmacol. Exp. Ther. 7, 557–576 (1915).

    CAS  Google Scholar 

  2. Dai, G., Levy, O. & Carrasco, N. Cloning and characterization of the thyroid iodide transporter . Nature 379, 458–460 (1996).

    Article  CAS  Google Scholar 

  3. Tazebay, U.H. et al. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Med. 6, 871 –878 (2000).

    Article  CAS  Google Scholar 

  4. Sawin, C.T. & Becker, D.V. Radioiodine and the treatment of hyperthyroidism: the early history. Thyroid 7, 163–176 (1996).

    Article  Google Scholar 

  5. Mandell, R.B., Mandell, L.Z. & Link, C.J. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res. 59, 661– 668 (1999).

    CAS  PubMed  Google Scholar 

  6. Taurog, A.M. in Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text 8th edn. (eds. Braverman, L.E. & Utiger, R.D.) 61– 85 (Lippincott, Williams & Wilkins, Philadelphia, 2000).

    Google Scholar 

  7. Maxon, H.R. et al. Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer. N. Engl. J. Med. 309, 937–941 (1983).

    Article  CAS  Google Scholar 

  8. Cobleigh et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic beast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17, 2639–2648 ( 1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Harvard Medical School Department of Medicine, Thyroid Unit, Massachusetts General Hospital, Boston, 02115, Massachusetts

    Gilbert H. Daniels

  2. Cancer Center, Massachusetts General Hospital, Boston, 02115, Massachusetts

    Daniel A. Haber

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  1. Gilbert H. Daniels
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  2. Daniel A. Haber
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Daniels, G., Haber, D. Will radioiodine be useful in treatment of breast cancer?. Nat Med 6, 859–860 (2000). https://doi.org/10.1038/78604

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