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A dual function for CD40 agonists

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CD40 ligation serves as a powerful mediator of protective and therapeutic immunity against foreign invaders and cancer cells in vivo. A study now shows that agonistic antibodies against CD40 may also be useful in the treatment of a chronic autoimmune inflammatory disease ( pages 673–679).

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Authors and Affiliations

  1. Department of Immunohematology and Blood tranfusion Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands

    E. Zanelli & R.E.M. Toes

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  1. E. Zanelli
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  2. R.E.M. Toes
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Zanelli, E., Toes, R. A dual function for CD40 agonists. Nat Med 6, 629–630 (2000). https://doi.org/10.1038/76197

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