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AMPA receptors jump the synaptic cleft

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Satake et al. show that glutamate release in the cerebellum causes heterosynaptic depression of GABA release and that AMPA receptors act presynaptically to mediate this phenomenon.

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Figure 1: Climbing fiber activation causes glutamate spread onto presynaptic AMPA receptors on basket cell terminals.

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Authors and Affiliations

  1. Departments of Cellular and Molecular Pharmacology, and Physiology, University of California, San Francisco, 94143–0450, California, USA

    Roger A. Nicoll, Matthew Frerking & Dietmar Schmitz

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  1. Roger A. Nicoll
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  2. Matthew Frerking
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  3. Dietmar Schmitz
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Nicoll, R., Frerking, M. & Schmitz, D. AMPA receptors jump the synaptic cleft. Nat Neurosci 3, 527–529 (2000). https://doi.org/10.1038/75689

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