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Neuroprotective autoimmunity—a double-edged sword?

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Glutamate receptors are thought to play an essential role in the central nervous system damage that results from certain neurological insults. A recent report indicates that immunization against a glutamate receptor subunit may have neuroprotective effects, but we must consider the potential for pathogenic autoimmune responses.

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Figure 1: Neuroprotective autoimmunity.

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Authors and Affiliations

  1. Department of Human Anatomy and Genetics, Oxford University, OX1 3QX, UK

    Matthew J.A. Wood

  2. Neurosciences Group Department of Clinical Neurology Institute of Molecular Medicine John Radcliffe Hospital Oxford University, OX3 9DU, UK

    Angela Vincent

Authors
  1. Matthew J.A. Wood
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  2. Angela Vincent
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Wood, M., Vincent, A. Neuroprotective autoimmunity—a double-edged sword?. Nat Med 6, 383–385 (2000). https://doi.org/10.1038/74641

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